Although it is considered less likely to cause drowsiness than older antihistamines, cetirizine can still affect some users. People taking it should understand the possible reactions and seek medical advice when symptoms become severe or persistent.
One possible effect is drowsiness and fatigue. Some users feel unusually sleepy or tired after taking the medicine, which can interfere with concentration. Anyone affected should avoid driving or operating machinery, while alcohol may increase the risk of sleepiness.
Another possible reaction is dry mouth. This can make speaking, eating and swallowing uncomfortable. Drinking water regularly or using sugar-free gum may help relieve the dryness.
Some users also report headaches after taking cetirizine. Mild cases may improve with rest and adequate fluids, but persistent or severe headaches require medical assessment.
The medicine can also cause nausea and stomach discomfort, including diarrhoea in some people. Anyone experiencing prolonged diarrhoea should seek medical advice, especially if they develop signs of dehydration.
Dizziness is another possible side effect. People who experience it should sit or lie down until they feel better and avoid activities that require full concentration.
A less common concern involves severe itching after stopping long-term use. In May 2025, the United States Food and Drug Administration (FDA) warned that some people who had taken cetirizine daily for months or years developed intense itching within days of discontinuing it. Some cases required medical attention.
Anyone considering stopping regular, long-term cetirizine use should discuss the decision with a healthcare professional. Severe itching after discontinuation should also prompt medical advice.
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